Rachel C. Phillips, John C. K. Chu, Alex A. Rafaniello, Matthew J. Gaunt

Selective endo-Cyclic α-Functionalization of Saturated N-Alkyl Piperidines

J. Org. Chem., 2025, 90, 12226 (10.1021/acs.joc.5c01742)

Marcus C. Grocott, Matthew J. Gaunt

One-carbon homologation of alkenes

Nature, 2025, 643, 130 (10.1038/s41586-025-09159-9)

Jesus Rodrigalvarez, Matthew J. Gaunt

Pd-Catalyzed C–H Activation vs β-H Elimination: An Experimental and Computational Insight into the Reactivity of Tertiary Alkylamines

ACS Catal., 2024, 14, 18831 (10.1021/acscatal.4c06160)

Harry C. Waller, Matthew J. Gaunt

Silyl Radicals as Single-Electron Reductants: α-Aminoalkyl Radical Formation via a Photocatalytic Oxidatively Initiated Radical Chain Process

J. Am. Chem. Soc., 2024, 146(38), 25894 (10.1021/jacs.4c08230)

Jianzhong Liu, Matthew J. Gaunt

Versatile, Modular, and General Strategy for the Synthesis of α-Amino Carbonyls

J. Am. Chem. Soc., 2024, 146(35), 24699 (10.1021/jacs.4c09434)

Alex A. Rafaniello, Roopender Kumar, Rachel C. Phillips, Matthew J. Gaunt

Modular Synthesis of Heterobenzylic Amines via Carbonyl Azinylative Amination

Angew. Chem. Int. Ed., 2024, e202408287 (10.1002/anie.202408287)

Joseph M. Phelps, Roopender Kumar, James D. Robinson, John C. K. Chu, Nils J. Flodén, Sarah Beaton, Matthew J. Gaunt

Multicomponent Synthesis of α-Branched Amines via a Zinc-Mediated Carbonyl Alkylative Amination Reaction

J. Am. Chem. Soc., 2024, 146(13), 9045 (10.1021/jacs.3c14037)

Milo Smith, Ryan Kang, Roopender Kumar, Biswarup Roy, Matthew J. Gaunt

Modular Synthesis of alpha-Branched Secondary Alkylamines via Visible-light-mediated Carbonyl Alkylative Amination

Chem. Sci., 2024, 15, 14888 (10.1039/D4SC03916E)

Bo Li, Ala Bunescu, Daniel Drazen, Katherine Rolph, Jean Michalland, Matthew J. Gaunt

Modular synthesis of alkyl chlorides via visible light mediated dual catalyzed aryl-chlorination of alkenes

Angew. Chem. Int. Ed., 2024, 63, e202405939 (10.1002/anie.202405939)

Jacek Zakrzewski, Polina Yaseneva, Connor J. Taylor, Matthew J. Gaunt, Alexei A. Lapkin

Scalable Palladium-Catalyzed C(sp3)–H Carbonylation of Alkylamines in Batch and Continuous Flow

Org. Process Rev. Dev., 2023, 27, 649 (10.1021/acs.oprd.2c00378)

Georgia R. Harris, Aaron D. Trowbridge, Matthew J. Gaunt

A Chiral Amine Transfer Approach to the Photocatalytic Asymmetric Synthesis of α-Trialkyl-α-tertiary Amines

Org. Lett., 2023, 25, 861 (10.1021/acs.orglett.2c04308)

Bo Li, Ala Bunescu, Matthew J. Gaunt

Multicomponent synthesis of α-chloro alkylboronic esters via visible-light-mediated dual catalysis

Chem., 2022, 9, 216 (10.1016/j.chempr.2022.10.010)

Sanesh Mistry, Roopender Kumar, Andrew Lister, Matthew J. Gaunt

C(sp3)–C(sp3) coupling of non-activated alkyl-iodides with electron-deficient alkenes via visible-light/silane-mediated alkylradical formation

Chem. Sci., 2022, 13, 13241 (10.1039/D2SC03516B)

Alexander Pomberger, Antonio A. Pedrina McCarthy, Ahmad Khan, Simon Sung, Connor J. Taylor, Matthew J. Gaunt, Lucy Colwell, David Walz, Alexei A. Lapkin

The effect of chemical representation on active machine learning towards closed-loop optimization

React. Chem. Eng., 2022, 7, 1368 (10.1039/D2RE00008C)

Jesus Rodrigalvarez, Luke A. Reeve, Javier Miró, Matthew J. Gaunt

Pd(II)-Catalysed Enantioselective C(sp3)-H Arylation of Cyclopropanes and Cyclobutanes Guided by Tertiary Alkylamines

J. Am. Chem. Soc., 2022, 144, 3939 (10.1021/jacs.1c11921)

Keishi Kohara, Aaron Trowbridge, Milo A. Smith, Matthew J. Gaunt

Thiol-Mediated α-Amino Radical Formation via Visible-Light-Activated Ion-Pair Charge-Transfer Complexes

J. Am. Chem. Soc., 2021, 143, 19268 (10.1021/jacs.1c09445)

J. Henry Blackwell, Georgia R. Harris, Milo A. Smith, Matthew J. Gaunt

Modular Photocatalytic Synthesis of α-Trialkyl-α-Tertiary Amines

J. Am. Chem. Soc., 2021, 143, 15946 (10.1021/jacs.1c07402)

Matthew J. Gaunt, Jacob M. Janey, Danielle M. Schultz, Tim Cernak

Myths of high-throughput experimentation and automation in chemistry

Chem, 2021, 7, 2259 (10.1016/j.chempr.2021.08.012)

Vivian M. Lechner, Manuel Nappi, Patrick J. Deneny, Sarah Folliet, John C. K. Chu, Matthew J. Gaunt

Visible-Light-Mediated Modification and Manipulation of Biomacromolecules

Chem. Rev., 2022, 122, 1752 (10.1021/acs.chemrev.1c00357)

Ala Bunescu, Yusra Abdelhamid, Matthew J. Gaunt

Multicomponent alkene azido-arylation by anion-mediated dual catalysis

Nature, 2021, 598, 597 (10.1038/s41586-021-03980-8)

Patrick J. Deneny, Roopender Kumar, Matthew J. Gaunt

Visible light-mediated radical fluoromethylation via halogen atom transfer activation of fluoroiodomethane

Chem. Sci., 2021, 12, 12812 (10.1039/d1sc04554g)

J. Henry Blackwell, Roopender Kumar, Matthew J. Gaunt

Visible-Light-Mediated Carbonyl Alkylative Amination to All-Alkyl α-Tertiary Amino Acid Derivatives

J. Am. Chem. Soc., 2021, 143, 3 (10.1021/jacs.0c12162)

Manuel Nappi, Alexandre Hofer, Shankar Balasubramanian, Matthew J. Gaunt

Selective Chemical Functionalization at N6-Methyladenosine Residues in DNA Enabled by Visible-Light-Mediated Photoredox Catalysis

J. Am. Chem. Soc., 2020, 142, 51 (10.1021/jacs.0c10616)

Kavoos Kolahdouzan, Roopender Kumar, Matthew J. Gaunt

Visible-light mediated carbonyl trifluoromethylative amination as a practical method for the synthesis of β-trifluoromethyl tertiary alkylamines.

Chem. Sci., 2020, 11 (10.1039/D0SC04853D)

William G. Whitehurst, Matthew J. Gaunt

Synthesis and Reactivity of Stable Alkyl-Pd(IV) Complexes Relevant to Monodentate N-directed C(sp3)–H Functionalization Processes

J. Am. Chem. Soc., 2020, 142, 33 (10.1021/jacs.0c04732)

Roopender Kumar, Nils J. Floden, William G. Whitehurst, Matthew J. Gaunt

A general carbonyl alkylative amination for tertiary amine synthesis

Nature, 2020, 581, 415 (10.1038/s41586-020-2213-0)

Aaron Trowbridge, Scarlett M. Walton, Matthew J. Gaunt

New Strategies for the Transition-Metal Catalyzed Synthesis of Aliphatic Amines

Chem. Rev., 2020, 120, 5 (10.1021/acs.chemrev.9b00462)

Jesus Rodrigalvarez, Manuel Nappi, Hiroki Azuma, Nils J. Floden, Matthew E. Burns, Matthew J. Gaunt

Catalytic C(sp3)–H bond activation in tertiary alkylamines

Nat. Chem., 2020, 12, 76 (10.1038/s41557-019-0393-8)

Dominik Reich, Aaron Trowbridge, Matthew J. Gaunt

Rapid syntheses of (−)‐FR901483 and (+)‐TAN1251C enabled by complexity‐generating photocatalytic olefin hydroaminoalkylation

Angew. Chem. Int. Ed., 2019, 59, 6 (10.1002/anie.201912010)

Nils J. Flodén, Aaron Trowbridge, Darren Willcox, Scarlett M. Walton, Yongjoon Kim, Matthew J. Gaunt

Streamlined synthesis of C(sp3)–H rich N-heterospirocycles enabled by visible-light-mediated photocatalysis

J. Am. Chem. Soc., 2019, 141, 8426 (110.1021/jacs.9b03372)

William G. Whitehurst, J. Henry Blackwell, Gary N. Hermann, Matthew J. Gaunt

Carboxylate-Assisted Oxidative Addition to Aminoalkyl-Pd(II) Complexes Enables Catalyzed C(sp3)–H Arylation of Alkylamines via Distinct Pd(II)/Pd(IV) Pathway

Angew. Chem. Int. Ed., 2019, 58, 9054 (10.1002/anie.201902838)

Danny K. H. Ho, Jonas Calleja, Matthew J. Gaunt

Palladium(II)-Catalyzed C(sp3)–H Activation of N,O-Ketals towards a Method for the β-Functionalization of Ketones

Synlett, 2019, 30, 454 (10.1055/s-0037-1611664)

Chuan He, William G. Whitehurst, Matthew J. Gaunt

Palladium-Catalyzed C(sp3)–H Bond Functionalization of Aliphatic Amines

Chem, 2019, 5, 1 (10.1016/j.chempr.2018.12.017)

Manuel Nappi, Matthew J. Gaunt

A Class of N–O-Type Oxidants To Access High-Valent Palladium Species

Organometallics, 2019, 38, 143 (10.1021/acs.organomet.8b00712)

Michael T. Taylor, Jennifer E. Nelson, Marcos G. Suero, Matthew J. Gaunt

A Protein Functionalization Platform Based on Selective Reactions at Methionine Residues

Nature, 2018, 562, 568 (10.1038/s41586-018-0608-y)

Cornelia S. Buettner, Darren Willcox, Ben G. N. Chappell, Matthew J. Gaunt

Mechanistic Investigation into the C(sp3)–H Acetoxylation of Morpholinones

Chem. Sci., 2018, 10, 83 (10.1039/C8SC03434F)

Aaron Trowbridge, Dominik Reich, Matthew Gaunt

Multicomponent synthesis of tertiary alkylamines by photocatalytic olefin-hydroaminoalkylation

Nature, 2018, 561, 522 (10.1038/s41586-018-0537-9)

Zhuang Mao Png, Jaime R. Cabrera-Pardo, Jorge Peiró Cadahíaa, Matthew J. Gaunt

Diastereoselective C−H Carbonylative Annulation of Aliphatic Amines: A Rapid Route to Functionalized γ-Lactams

Chem. Sci., 2018, 9, 7628 (10.1039/C8SC02855A)

Manuel Nappi, Chuan He, William G. Whitehurst, Ben G. N. Chappell, Matthew J. Gaunt

Selective Reductive Elimination at Alkyl Pd(IV) via Dissociative Ligand Ionization Enables Catalytic C(sp3)−H Amination to Azetidines

Angew. Chem. Int. Ed., 2018, 57, 3178 (10.1002/anie.201800519)

Kirsten F. Hogg, Aaron Trowbridge, Andres Alvarez-Pérez, Matthew J. Gaunt

The α-Tertiary Amine Motif Drives Remarkable Selectivity for Palladium-Catalyzed Carbonylation of Methylene C−H Bonds

Chem. Sci., 2017, 8, 8198 (10.1039/C7SC03876C)

Jaime R. Cabrera‐Pardo, Aaron Trowbridge, Manuel Nappi, Kyohei Ozaki, Matthew J. Gaunt

Selective Palladium(II)-Catalyzed Carbonylation of β Methylene C−H Bonds in Aliphatic Amines

Angew. Chem. Int. Ed., 2017, 56, 11958 (10.1002/anie.201706303)

Daniel H. Lukamto, Matthew J. Gaunt

Enantioselective Copper-Catalyzed Arylation-Driven Semipinacol Rearrangement of Tertiary Allylic Alcohols with Diaryliodonium Salts

J. Am. Chem. Soc., 2017, 139, 9160 (10.1021/jacs.7b05340)

Chuan He, Matthew J. Gaunt

Ligand-Assisted Palladium-Catalyzed C−H Alkenylation of Aliphatic Amines for the Synthesis of Functionalized Pyrrolidines

Chem. Sci., 2017, 8, 3586 (10.1039/C7SC00468K)

Patrick Williamson, Alicia Galván, Matthew J. Gaunt

Cobalt-Catalyzed C−H Carbonylative Cyclisation of Aliphatic Amides

Chem. Sci., 2017, 8, 2588 (10.1039/C6SC05581H)

Adam P. Smalley, James D. Cuthbertson, Matthew J. Gaunt

Palladium-Catalyzed Enantioselective C−H Activation of Aliphatic Amines Using Chiral Anionic BINOL-Phosphoric Acid Ligands

J. Am. Chem. Soc., 2017, 139, 1412 (10.1021/jacs.6b12234)

Darren Willcox, Ben G. N. Chappell, Kirsten F. Hogg, Jonas Calleja, Adam P. Smalley, Matthew J. Gaunt

A General Catalytic β-C−H Carbonylation of Aliphatic Amines to β-Lactams

Science, 2016, 354, 851 (10.1126/science.aaf9621)

Rodolphe Beaud, Robert J. Phipps, Matthew J. Gaunt

Enantioselective Cu-Catalyzed Arylation of Secondary Phosphine Oxides with Diaryliodonium Salts towards the Synthesis of P-Chiral Phosphines

J. Am. Chem. Soc., 2016, 138, 13183 (10.1021/jacs.6b09334)

Jacek Zakrzewski, Adam P. Smalley, Mikhail A. Kabeshov, Matthew J. Gaunt, Alexei A. Lapkin

Continuous-Flow Synthesis and Derivitization of Aziridines through Palladium-Catalyzed C(sp3)−H Activation

Angew. Chem. Int. Ed., 2016, 55, 9024 (10.1002/anie.201602483)

James C. Fox, Ruth E. Gilligan, Andrew K. Pitts, H. R. Bennett, Matthew J. Gaunt

The Total Synthesis of K-252c (Staurosporinone) via a Sequential C−H Functionalization Strategy

Chem. Sci., 2016, 7, 2706 (10.1039/C5SC04399A)

Alice E. Williamson, Tifelle Ngouansavanh, Robert D. M. Pace, Anna E. Allen, James D. Cuthbertson, Matthew J. Gaunt

Rapid Generation of Complex Molecular Architectures by a Catalytic Enantioselective Dearomatization Strategy

Synlett, 2016, 27, 116 (10.1055/s-0035-1560377)

Chuan He, Matthew J. Gaunt

Ligand-Enabled Catalytic C−H Arylation of Aliphatic Amines by a Four-Membered Ring Cyclopalladation Pathway

Angew. Chem. Int. Ed., 2015, 54, 15840 (10.1002/anie.201508912)

Jonas Calleja, Daniel Pla, Timothy W. Gorman, Victoriano Domingo, Benjamin Haffemayer, Matthew J. Gaunt

A Steric-Tethering Approach Enables Palladium-Catalyzed C−H Activation of Primary Amino Alcohols

Nat. Chem., 2015, 7, 1009 (10.1038/nchem.2367)

Adam P. Smalley, Matthew J. Gaunt

Mechanistic Insights Into the Palladium-Catalyzed Aziridination of Aliphatic Amines by C−H Activation

J. Am. Chem. Soc., 2015, 137, 10362 (10.1021/jacs.5b05529)

Elise Cahard, Henry P. J. Male, Matthieu Tissot, Matthew J. Gaunt

Enantioselective and Regiodivergent Copper-Catalyzed Electrophilic Arylation of Allylic Amides with Diaryliodonium Salts

J. Am. Chem. Soc., 2015, 137, 7986 (10.1021/jacs.5b03937)

Dean Holt, Matthew J. Gaunt

Copper-Catalyzed Oxy-Alkenylation of Homoallylic Alcohols to Generate Functional Syn-1,3-Diol Derivatives

Angew. Chem. Int. Ed., 2015, 54, 7857 (10.1002/anie.201501995)

Andrew K. Pitts, Fionn O'Hara, Robert H. Snell, Matthew J. Gaunt

A Concise and Scalable Strategy for the Total Synthesis of Dictyodendrin B Based on Sequential C−H Functionalization

Angew. Chem. Int. Ed., 2015, 54, 5451 (10.1002/anie.201500067)

Louis Chan, Andrew McNally, Qiao Y. Toh, Abraham Mendoza, Mathew J. Gaunt

A Counterion Triggered Arylation Strategy Using Diaryliodonium Fluorides

Chem. Sci., 2015, 6, 1277 (10.1039/C4SC02856B)

Matthieu Tissot, Robert J. Phipps, Catherine Lucas, Rafael M. Leon, Robert D. M. Pace, Tifelle Ngouansavanh, Matthew J. Gaunt

Gram-Scale Enantioselective Formal Synthesis of Morphine Through an Ortho-Para Oxidative Phenolic Coupling Strategy

Angew. Chem. Int. Ed., 2014, 53, 13498 (10.1002/anie.201408435)

Fengzhi Zhang, Shoubhik Das, Andrew J. Walkinshaw, Alicia Casitas, Michael Taylor, Marcos G. Suero, Matthew J. Gaunt

Cu-Catalyzed Cascades to Carbocycles: Union of Diaryliodonium Salts with Alkenes or Alkynes Exploiting Remote Carbocations

J. Am. Chem. Soc., 2014, 136, 8851 (10.1021/ja504361y)

Andrew McNally, Benjamin Haffemayer, Beatrice S. L. Collins, Matthew J. Gaunt

Palladium-Catalyzed C−H Activation of Aliphatic Amines to Give Strained Nitrogen Heterocycles

Nature, 2014, 510, 129 (10.1038/nature13389)

Andrew J. Walkinshaw, Wenshu Xu, Marcos G. Suero, Matthew J. Gaunt

Copper-Catalyzed Carboarylation of Alkynes via Vinyl Cations

J. Am. Chem. Soc., 2013, 135, 12532 (10.1021/ja405972h)

Elise Cahard, Nadine Bremeyer, Matthew J. Gaunt

Copper-Catalyzed Intramolecular Electrophilic Carbofunctionalization of Allylic Amides

Angew. Chem. Int. Ed., 2013, 52, 9284 (10.1002/anie.201303724)

Beatrice S. L. Collins, Marcos G. Suero, Matthew J. Gaunt

Copper-Catalyzed Arylative Meyer-Schuster Rearrangement of Propargylic Alcohols to Complex Enones Using Diaryliodonium Salts

Angew. Chem. Int. Ed., 2013, 52, 5799 (10.1002/anie.201301529)

Marcos G. Suero, Elliott D. Bayle, Beatrice S. L. Collins, Matthew J. Gaunt

Copper-Catalyzed Electrophilic Carbofunctionalization of Alkynes to Highly Functionalized Tetrasubstituted Alkenes

J. Am. Chem. Soc., 2013, 135, 5322 (10.1021/ja401840j)

Qiao Yan Toh, Andrew McNally, Silvia Vera, Nico Erdmann, Matthew J. Gaunt

Organocatalytic C−H Bond Arylation of Aldehydes to Bis-Heteroaryl Ketones

J. Am. Chem. Soc., 2013, 135, 3772 (10.1021/ja400051d)

Lindsay McMurray, Elizabeth M. Beck, Matthew J. Gaunt

Chemical Synthesis of Aspidosperma Alkaloids Inspired by the Reverse of the Biosynthesis of the Rhazinilam Family of Natural Products

Angew. Chem. Int. Ed., 2012, 51, 9288 (10.1002/anie.201204151)

Robert J. Phipps, Lindsay McMurray, Stefanie Ritter, Hung A. Duong, Matthew J. Gaunt

Copper-Catalyzed Alkene Arylation with Diaryliodonium Salts

J. Am. Chem. Soc., 2012, 134, 10773 (10.1021/ja3039807)

Aurélien Bigot, Alice E. Williamson, Matthew J. Gaunt

Enantioselective α-Arylation of N-Acyloxazolidinones With Copper(II)-Bisoxazoline Catalysts and Diaryliodonium Salts

J. Am. Chem. Soc., 2011, 133, 13778 (10.1021/ja206047h)

Rafael Leon, Anup Jawalekar, Thomas Rederta, Matthew J. Gaunt

Catalytic Enantioselective Assembly of Complex Molecules Containing Embedded Quaternary Stereogenic Centres from Simple Anisidine Derivatives

Chem. Sci., 2011, 2, 1487 (10.1039/C1SC00218J)

Lindsay McMurray, Fionn O'Haraa, Matthew J. Gaunt

Recent Development in Natural Product Synthesis Using Metal-Catalyzed C−H Bond Functionalization

Chem. Soc. Rev., 2011, 40, 1885 (10.1039/C1CS15013H)

Matthew J. Tredwell, Moises Gulias, Nadine Bremeyer, Carin C. C. Johansson, Beatrice S. L. Collins, Matthew J. Gaunt

Palladium(II)-Catalyzed C−H Bond Arylation of Electron-Deficient Arenes at Room Temperature

Angew. Chem. Int. Ed., 2011, 50, 1076 (10.1002/anie.201005990)

Hung A. Duong, Ruth E. Gilligan, Michael L. Cooke, Robert J. Phipps, Matthew J. Gaunt

Copper(II)-Catalyzed Meta-Selective Direct Arylation of α-Aryl Carbonyl Compounds

Angew. Chem. Int. Ed., 2011, 50, 463 (10.1002/anie.201004704)

Claire‐Lise Ciana, Robert J. Phipps, Jochen R. Brandt, Falco‐Magnus Meyer, Matthew J. Gaunt

A Highly Para-Selective Copper(II)-Catalyzed Direct Arylation of Aniline and Phenol Derivatives

Angew. Chem. Int. Ed., 2011, 50, 458 (10.1002/anie.201004703)

Benjamin Haffemayer, Moises Guliasa, Matthew J. Gaunt

Amine Directed Pd(II)-Catalyzed C−H Bond Functionalization Under Ambient Conditions

Chem. Sci., 2011, 2, 312 (10.1039/C0SC00367K)

Neil P. Grimster, Donna A. A. Wilton, Louis K. M. Chan, Christopher R. A. Godfrey, Clive Green, Dafydd R. Owen, Matthew J. Gaunt

Alkynes to (E)-Enolates Using Tandem Catalysis: Stereoselective Anti-Aldol and Syn-[3,3]-Rearrangement Reactions

Tetrahedron, 2010, 66, 6429 (10.1016/j.tet.2010.05.045)

Robert J. Phipps, Matthew J. Gaunt

A Meta-Selective Copper-Catalyzed C−H Bond Arylation

Science, 2009, 323, 1593 (10.1126/science.1169975)

James A. Jordan-Hore, Carin C. C. Johansson, Moises Gulias, Elizabeth M. Beck, Matthew J. Gaunt

Oxidative Pd(II)-Catalyzed C−H Bond Amination to Carbazole at Ambient Temperature

J. Am. Chem. Soc., 2008, 130, 16184 (10.1021/ja806543s)

Robert J. Phipps, Neil P. Grimster, Matthew J. Gaunt

Cu(II)-Catalyzed Direct and Site-Selective Arylation of Indoles Under Mild Conditions

J. Am. Chem. Soc., 2008, 130, 8172 (10.1021/ja801767s)

Carin C. C. Johansson, Nadine Bremeyer, Steven V. Ley, Dafydd R. Owen, Stephen C. Smith, Matthew J. Gaunt

Synthesis of Rhazinicine by a Metal-Catalyzed C−H Bond Functionalization Strategy

Angew. Chem. Int. Ed., 2008, 47, 3004 (10.1002/anie.200602129)

Ngoc T. Vo, Robert D. M. Pace, Fionn O'Har, Matthew J. Gaunt

An Enantioselective Organocatalytic Oxidative Dearomatization Strategy

J. Am. Chem. Soc., 2008, 130, 404 (10.1021/ja077457u)

Carin C. C. Johansson, Matthew J. Gaunt

Recent Developments in the Use of Catalytic Asymmetric Ammonium Enolates in Chemical Synthesis

Chem. Rev., 2007, 107, 5596 (10.1021/cr0683764)

Carin C. C. Johansson, Andy McNally, Ngoc T. Vo, Matthew J. Gaunt

Enantioselective Organocatalysis Review

Drug Discov. Today, 2007, 12, 8 (10.1016/j.drudis.2006.11.004)

Carin C. C. Johansson, Nadine Bremeyer, Steven V. Ley, Dafydd R. Owen, Stephen C. Smith, Matthew J. Gaunt

Enantioselective Catalytic Intramolecular Cyclopropanation Using Modified Cinchona Alkaloid Organocatalysts

Angew. Chem. Int. Ed., 2006, 45, 6024 (10.1002/anie.200602129)

Elizabeth M. Beck, Neil P. Grimster, Richard Hatley, Matthew J. Gaunt

Mild Aerobic Oxidative Palladium(II)-Catalyzed C−H Bond Functionalization: Regioselective and Switchable C−H Alkenylation and Annulation of Pyrroles

J. Am. Chem. Soc., 2006, 128, 2528 (10.1021/ja058141u)

Andrew McNally, Brian Evans, Matthew J. Gaunt

Organocatalytic Sigmatropic Reactions: Development of a [2,3]-Wittig Rearrangement Through Secondary Amine Catalysis

Angew. Chem. Int. Ed., 2006, 45, 2116 (10.1002/anie.200504301)

Neil P. Grimster, Carolyn Gauntlett, Christopher R. A. Godfrey, Matthew J. Gaunt

Palladium-Catalyzed Intermolecular Alkenylation of Indoles via Solvent-Controlled Regioselective C−H Functionalization

Angew. Chem. Int. Ed., 2005, 44, 3125 (10.1002/anie.200500468)

Charles D. Papageorgiou, Maria A. Cubillo de Dios, Steven V. Ley, Matthew J. Gaunt

Enantioselective Organocatalytic Cyclopropanation via Ammonium Ylides

Angew. Chem. Int. Ed., 2004, 43, 4641 (10.1002/anie.200460234)

Nadine Bremeyer, Stephen C. Smith, Steven V. Ley, Matthew J. Gaunt

An Intramolecular Organocatalytic Cyclopropanation Reaction

Angew. Chem. Int. Ed., 2004, 43, 2681 (10.1002/anie.200454007)

Charles D. Papageorgiou, Steven V. Ley, Matthew J. Gaunt

Organic-Catalyst-Mediated Cyclopropanation Reaction

Angew. Chem. Int. Ed., 2003, 42, 828 (10.1002/anie.200390222)

Helen F. Sneddon, Alexandra van den Heuvel, Anna K. H. Hirsch, Richard A. Booth, David M. Shaw, Matthew J. Gaunt, Steven V. Ley

Double Conjugate Addition of Dithiols to Propargylic Carbonyl Systems to Generate Protected 1,3-Dicarbonyl Compounds

J. Org. Chem., 2006, 71, 2715 (10.1021/jo052514s)

Shigeru Kawahara, Matthew J. Gaunt, Alessandra Scolaro, Shigeo Yamanoi, Steven V. Ley

Synthesis of the EF Fragment of Spongistatin 1

Synlett, 2005, 13, 2031 (10.1055/s-2005-871960)

Matthew Ball, Matthew J. Gaunt, David F. Hook, Alan S. Jessiman, Shigeru Kawahara, Paolo Orsini, Alessandra Scolaro, Adam C. Talbot, Huw R. Tanner, Shigeo Yamanoi, Steven V. Ley

Total Synthesis of Spongistatin 1: Exploiting the Latent Pseudo-Symmetry

Angew. Chem. Int. Ed., 2005, 44, 5433 (10.1002/anie.200502008)

Matthew J. Gaunt, Alan S. Jessiman, Paolo Orsini, Huw R. Tanner, David F. Hook, Steven V. Ley

Synthesis of C-1-C-28 ABCD Unit of Spongistatin 1

Org. Lett., 2003, 5, 4819 (10.1021/ol035849+)

Matthew J. Gaunt, David F. Hook, Huw R. Tanner, Steven V. Ley

A Practical and Efficient Synthesis of the C-16-C-28 Spiroketal Fragment (CD) of the Spongistatins

Org. Lett., 2003, 5, 4815 (10.1021/ol035848h)

Helen F. Sneddon, Matthew J. Gaunt, Steven V. Ley

Addition of Dithiols to Bis-Ynones: Development of a Versatile Platform for the Synthesis of Polyketide Natural Products

Org. Lett., 2003, 5, 1147 (10.1021/ol034248f)

Matthew J. Gaunt, Helen F. Sneddon, Peter R. Hewitt, Paolo Orsini, David F. Hooka, Steven V. Ley

Development of β-Keto 1,3-Dithianes as Versatile Intermediates for Organic Synthesis

Org. Biomol. Chem., 2003, 1, 15 (10.1039/B208982C)

Amos B. Smith, Suresh M. Pitram, Armen M. Boldi, Matthew J. Gaunt, Chris Sfouggatakis, William H. Moser

Multicomponent Linchpin Couplings. Reaction of Dithiane Anions with Epoxides, Epichlorohydrin and Vinyl Epoxides: Efficient, Rapid and Stereocontrolled Assembly of Advanced Fragments for Complex Molecule Synthesis

J. Am. Chem. Soc., 2003, 125, 14435 (10.1021/ja0376238)

Amos B. Smith, Suresh M. Pitram, Matthew J. Gaunt, Sergey A. Kozmin

Dithiane Additions to Vinyl Epoxides: Steric Control Over S N 2 and S N 2' Manifolds

J. Am. Chem. Soc., 2002, 124, 14516 (10.1021/ja0283100)

Joseph A. Wright, Matthew J. Gaunt, Jonathan B. Spencer

Novel Anti-Markovnikov Regioselectivity in the Wacker Reaction of Styrenes

Chem. Eur. J., 2006, 12, 949 (10.1002/chem.200400644)

Jinquan Yu, Matthew J. Gaunt, Jonathan B. Spencer

Convenient Preparation of Pure Trans-Arylalkenes via Palladium(II)-Catalyzed Isomerization of the Cis-Alkenes

J. Org. Chem., 2002, 67, 4627 (10.1021/jo015880u)

Matthew J. Gaunt, Jinquan Yu, Jonathan B. Spencer

Evidence that the Availability of an Allylic Hydrogen Governs the Regioselectivity of the Wacker Oxidation

Chem. Comm., 2001, 1844 (10.1039/B103066N)

Matthew J. Gaunt, Jonathan B. Spencer

Derailing the Wacker Oxidation: Development of a Palladium-Catalyzed Amidation Reaction

Org. Lett., 2001, 3, 25 (10.1021/ol0066882)

Edward A. Papageorgiou, Matthew J. Gaunt, Jinquan Yu, Jonathan B. Spencer

Selective Hydrogenolysis of Novel Benzyl Carbamate Protecting Groups

Org. Lett., 2000, 2, 1049 (10.1021/ol005589l)

Matthew J. Gaunt, Carlos E. Boschetti, Jinquan Yu, Jonathan B. Spencer

Preferential Hydrogenolysis of NAP Esters Provides a New Orthogonal Protecting Group Strategy for Carboxylic Acids

Tetrahedron Lett., 1999, 40, 1803 (10.1016/S0040-4039(99)00014-3)

Matthew J. Gaunt, Jinquan Yu, Jonathan B. Spencer

Rational Design of Benzyl Type Protecting Groups Allows Sequential Deprotection of Hydroxyl Groups by Catalytic Hydrogenolysis

J. Org. Chem., 1998, 63, 4172 (10.1021/jo980823v)