76. J. Am. Chem. Soc. 2019, 141, 8426, Streamlined synthesis of C(sp3)–H rich N-heterospirocycles enabled by visible-light-mediated photocatalysis

DOI:110.1021/jacs.9b03372

70. Chem. Sci., 2018, 10, 83, Mechanistic Investigation into the C(sp3)–H Acetoxylation of Morpholinones

DOI:10.1039/C8SC03434F

69. Nature, 2018, 561, 522, Multicomponent synthesis of tertiary alkylamines by photocatalytic olefin-hydroaminoalkylation

DOI:10.1038/s41586-018-0537-9

68. Chem. Sci., 2018, 9, 7628, Diastereoselective C−H Carbonylative Annulation of Aliphatic Amines: A Rapid Route to Functionalized γ-Lactams

DOI:10.1039/C8SC02855A

67. Angew. Chem. Int. Ed., 2018, 57, 3178, Selective Reductive Elimination at Alkyl Pd(IV) via Dissociative Ligand Ionization Enables Catalytic C(sp3)−H Amination to Azetidines

DOI:10.1002/anie.201800519

66. Chem. Sci., 2017, 8, 8198, The α-Tertiary Amine Motif Drives Remarkable Selectivity for Palladium-Catalyzed Carbonylation of Methylene C−H Bonds

DOI:10.1039/C7SC03876C

65. Angew. Chem. Int. Ed., 2017, 56, 11958, Selective Palladium(II)-Catalyzed Carbonylation of β Methylene C−H Bonds in Aliphatic Amines

DOI:10.1002/anie.201706303

64. J. Am. Chem. Soc., 2017, 139, 9160, Enantioselective Copper-Catalyzed Arylation-Driven Semipinacol  Rearrangement of Tertiary Allylic Alcohols with Diaryliodonium Salts

DOI:10.1021/jacs.7b05340

63. Chem. Sci., 2017, 8, 3586, Ligand-Assisted Palladium-Catalyzed C−H Alkenylation of Aliphatic Amines for the Synthesis of Functionalized Pyrrolidines

DOI:10.1039/C7SC00468K

62. Chem. Sci., 2017, 8, 2588, Cobalt-Catalyzed C−H Carbonylative Cyclisation of Aliphatic Amides

DOI:10.1039/C6SC05581H

61. J. Am. Chem. Soc., 2017, 139, 1412, Palladium-Catalyzed Enantioselective C−H Activation of Aliphatic Amines Using Chiral Anionic BINOL-Phosphoric Acid Ligands

DOI:10.1021/jacs.6b12234

60. Science, 2016, 354, 851, A General Catalytic β-C−H Carbonylation of Aliphatic Amines to β-Lactams

DOI:10.1126/science.aaf9621

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59. J. Am. Chem. Soc., 2016, 138, 13183, Enantioselective Cu-Catalyzed Arylation of Secondary Phosphine Oxides with Diaryliodonium Salts towards the Synthesis of P-Chiral Phosphines

DOI:10.1021/jacs.6b09334

58. Angew. Chem. Int. Ed., 2016, 55, 9024, Continuous-Flow Synthesis and Derivitization of Aziridines through Palladium-Catalyzed C(sp3)−H Activation

DOI:10.1002/anie.201602483

57. Chem. Sci., 2016, 7, 2706, The Total Synthesis of K-252c (Staurosporinone) via a Sequential C−H Functionalization Strategy

DOI:10.1039/C5SC04399A

56. Synlett, 2016, 27, 116, Rapid Generation of Complex Molecular Architectures by a Catalytic Enantioselective Dearomatization Strategy

DOI:10.1055/s-0035-1560377

55. Angew. Chem. Int. Ed., 2015, 54, 15840, Ligand-Enabled Catalytic C−H Arylation of Aliphatic Amines by a Four-Membered Ring Cyclopalladation Pathway

DOI:10.1002/anie.201508912

54. Nat. Chem., 2015, 7, 1009, A Steric-Tethering Approach Enables Palladium-Catalyzed C−H Activation of Primary Amino Alcohols

DOI:10.1038/nchem.2367

53. J. Am. Chem. Soc., 2015, 137, 10362, Mechanistic Insights Into the Palladium-Catalyzed Aziridination of Aliphatic Amines by C−H Activation

DOI:10.1021/jacs.5b05529

52. J. Am. Chem. Soc., 2015, 137, 7986, Enantioselective and Regiodivergent Copper-Catalyzed Electrophilic Arylation of Allylic Amides with Diaryliodonium Salts

DOI:10.1021/jacs.5b03937

51. Angew. Chem. Int. Ed., 2015, 54, 7857, Copper-Catalyzed Oxy-Alkenylation of Homoallylic Alcohols to Generate Functional Syn-1,3-Diol Derivatives

DOI:10.1002/anie.201501995

50. Angew. Chem. Int. Ed., 2015, 54, 5451, A Concise and Scalable Strategy for the Total Synthesis of Dictyodendrin B Based on Sequential C−H Functionalization 

DOI:10.1002/anie.201500067

49. Chem. Sci., 2015, 6, 1277, A Counterion Triggered Arylation Strategy Using Diaryliodonium Fluorides 

DOI:10.1039/C4SC02856B

48. Angew. Chem. Int. Ed., 2014, 53, 13498, Gram-Scale Enantioselective Formal Synthesis of Morphine Through an Ortho-Para Oxidative Phenolic Coupling Strategy

DOI:10.1002/anie.201408435

47. J. Am. Chem. Soc., 2014, 136, 8851, Cu-Catalyzed Cascades to Carbocycles: Union of Diaryliodonium Salts with Alkenes or Alkynes Exploiting Remote Carbocations

DOI:10.1021/ja504361y

46. Nature, 2014, 510, 129, Palladium-Catalyzed C−H Activation of Aliphatic Amines to Give Strained Nitrogen Heterocycles

DOI:10.1038/nature13389

45. J. Am. Chem. Soc., 2013, 135, 12532, Copper-Catalyzed Carboarylation of Alkynes via Vinyl Cations

DOI:10.1021/ja405972h

44. Angew. Chem. Int. Ed., 2013, 52, 9284, Copper-Catalyzed Intramolecular Electrophilic Carbofunctionalization of Allylic Amides

DOI:10.1002/anie.201303724

43. Angew. Chem. Int. Ed., 2013, 52, 5799, Copper-Catalyzed Arylative Meyer-Schuster Rearrangement of Propargylic Alcohols to Complex Enones Using Diaryliodonium Salts

DOI:10.1002/anie.201301529

42. J. Am. Chem. Soc., 2013, 135, 5322, Copper-Catalyzed Electrophilic Carbofunctionalization of Alkynes to Highly Functionalized Tetrasubstituted Alkenes

DOI:10.1021/ja401840j

41. J. Am. Chem. Soc., 2013, 135, 3772, Organocatalytic C−H Bond Arylation of Aldehydes to Bis-Heteroaryl Ketones

DOI:10.1021/ja400051d

40. Angew. Chem. Int. Ed., 2012, 51, 9288, Chemical Synthesis of Aspidosperma Alkaloids Inspired by the Reverse of the Biosynthesis of the Rhazinilam Family of Natural Products

DOI:10.1002/anie.201204151

39. J. Am. Chem. Soc., 2012, 134, 10773, Copper-Catalyzed Alkene Arylation with Diaryliodonium Salts

DOI:10.1021/ja3039807

38. J. Am. Chem. Soc., 2011, 133, 13778, Enantioselective α-Arylation of N-Acyloxazolidinones With Copper(II)-Bisoxazoline Catalysts and Diaryliodonium Salts

DOI:10.1021/ja206047h

37. Chem. Sci., 2011, 2, 1487, Catalytic Enantioselective Assembly of Complex Molecules Containing Embedded Quaternary Stereogenic Centres from Simple Anisidine Derivatives

DOI:10.1039/C1SC00218J

36. Chem. Soc. Rev., 2011, 40, 1885, Recent Development in Natural Product Synthesis Using Metal-Catalyzed C−H Bond Functionalization

DOI:10.1039/C1CS15013H

35. Angew. Chem. Int. Ed., 2011, 50, 1076, Palladium(II)-Catalyzed C−H Bond Arylation of Electron-Deficient Arenes at Room Temperature

DOI:10.1002/anie.201005990

34. Angew. Chem. Int. Ed., 2011, 50, 463, Copper(II)-Catalyzed Meta-Selective Direct Arylation of α-Aryl Carbonyl Compounds

DOI:10.1002/anie.201004704

33. Angew. Chem. Int. Ed., 2011, 50, 458, A Highly Para-Selective Copper(II)-Catalyzed Direct Arylation of Aniline and Phenol Derivatives

DOI:10.1002/anie.201004703

32. Chem. Sci., 2011, 2, 312, Amine Directed Pd(II)-Catalyzed C−H Bond Functionalization Under Ambient Conditions

DOI:10.1039/C0SC00367K

31. Tetrahedron, 2010, 66, 6429, Alkynes to (E)-Enolates Using Tandem Catalysis: Stereoselective Anti-Aldol and Syn-[3,3]-Rearrangement Reactions

DOI:10.1016/j.tet.2010.05.045

30. Science, 2009, 323, 1593, A Meta-Selective Copper-Catalyzed C−H Bond Arylation

DOI:10.1126/science.1169975

29. J. Am. Chem. Soc., 2008, 130, 16184, Oxidative Pd(II)-Catalyzed C−H Bond Amination to Carbazole at Ambient Temperature

DOI:10.1021/ja806543s

28. J. Am. Chem. Soc., 2008, 130, 8172, Cu(II)-Catalyzed Direct and Site-Selective Arylation of Indoles Under Mild Conditions

DOI:10.1021/ja801767s

27. Angew. Chem. Int. Ed., 2008, 47, 3004, Synthesis of Rhazinicine by a Metal-Catalyzed C−H Bond Functionalization Strategy

DOI:10.1002/ange.200602129

26. J. Am. Chem. Soc., 2008, 130, 404, An Enantioselective Organocatalytic Oxidative Dearomatization Strategy

DOI:10.1021/ja077457u

25. Chem. Rev., 2007, 107, 5596, Recent Developments in the Use of Catalytic Asymmetric Ammonium Enolates in Chemical Synthesis 

DOI:10.1021/cr0683764

24. Drug Discov. Today, 2007, 12, 8, Enantioselective Organocatalysis Review

DOI:10.1016/j.drudis.2006.11.004

23. Angew. Chem. Int. Ed., 2006, 45, 6024, Enantioselective Catalytic Intramolecular Cyclopropanation Using Modified Cinchona Alkaloid Organocatalysts

DOI:10.1002/anie.200602129

22. J. Am. Chem. Soc., 2006, 128, 2528, Mild Aerobic Oxidative Palladium(II)-Catalyzed C−H Bond Functionalization: Regioselective and Switchable C−H Alkenylation and Annulation of Pyrroles

DOI:10.1021/ja058141u

21. Angew. Chem. Int. Ed., 2006, 45, 2116, Organocatalytic Sigmatropic Reactions: Development of a [2,3]-Wittig Rearrangement Through Secondary Amine Catalysis

DOI:10.1002/anie.200504301

20. Angew. Chem. Int. Ed., 2005, 44, 3125, Palladium-Catalyzed Intermolecular Alkenylation of Indoles via Solvent-Controlled Regioselective C−H Functionalization

DOI:10.1002/anie.200500468

19. Angew. Chem. Int. Ed., 2004, 43, 4641, Enantioselective Organocatalytic Cyclopropanation via Ammonium Ylides

DOI:10.1002/anie.200460234

18. Angew. Chem. Int. Ed., 2004, 43, 2681, An Intramolecular Organocatalytic Cyclopropanation Reaction 

DOI:10.1002/anie.200454007

17. Angew. Chem. Int. Ed., 2003, 42, 828, Organic-Catalyst-Mediated Cyclopropanation Reaction

DOI:10.1002/anie.200390222

Postdoctoral Studies: Professor Steven Ley

16. J. Org. Chem., 2006, 7, 2715, Double Conjugate Addition of Dithiols to Propargylic Carbonyl Systems to Generate Protected 1,3-Dicarbonyl Compounds 

DOI:10.1021/jo052514s

15. Synlett, 2005, 13, 2031, Synthesis of  the EF Fragment of Spongistatin 1

DOI:10.1055/s-2005-871960

14. Angew. Chem. Int. Ed., 2005, 44, 5433, Total Synthesis of Spongistatin 1: Exploiting the Latent Pseudo-Symmetry

DOI:10.1002/anie.200502008

13. Org. Lett., 2003, 5, 4819, Synthesis of C-1-C-28 ABCD Unit of Spongistatin 1

DOI:10.1021/ol035849+

12. Org. Lett., 2003, 5, 4815, A Practical and Efficient Synthesis of the C-16-C-28 Spiroketal Fragment (CD) of the Spongistatins

DOI:10.1021/ol035848h

11. Org. Lett., 2003, 5, 1147, Addition of Dithiols to Bis-Ynones: Development of a Versatile Platform for the Synthesis of Polyketide Natural Products

DOI:10.1021/ol034248f

10. Org. Biomol. Chem., 2003, 1, 15, Development of β-Keto 1,3-Dithianes as Versatile Intermediates for Organic Synthesis

DOI:10.1039/B208982C

Postdoctoral Studies (with Professor Amos Smith)

9. Amos B. Smith, Suresh M. Pitram, Armen M. Boldi, Matthew J. Gaunt, Chris Sfouggatakis, William H. Moser

Multicomponent Linchpin Couplings. Reaction of Dithiane Anions with Epoxides, Epichlorohydrin and Vinyl Epoxides: Efficient, Rapid and Stereocontrolled Assembly of Advanced Fragments for Complex Molecule Synthesis

J. Am. Chem. Soc. 2003, 125, 14435 (10.1021/ja0376238)

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8. Amos B. Smith, Suresh M. Pitram, Matthew J. Gaunt, Sergey A. Kozmin

Dithiane Additions to Vinyl Epoxides: Steric Control Over SN2 and SN2' Manifolds

J. Am. Chem. Soc. 2002, 124, 14516 (10.1021/ja0283100)

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PhD Studies (with Dr Jonathan Spencer)

7. Joseph A. Wright, Matthew J. Gaunt, Jonathan B. Spencer

Novel Anti-Markovnikov Regioselectivity in the Wacker Reaction of Styrenes

Chem. Eur. J. 2006, 12, 949 (10.1002/chem.200400644)

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6. Jinquan Yu, Matthew J. Gaunt, Jonathan B. Spencer

Convenient Preparation of Pure Trans-Arylalkenes via Palladium(II)-Catalyzed Isomerization of the Cis-Alkenes

J. Org. Chem. 2002, 67, 4627 (10.1021/jo015880u)

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5. Matthew J. Gaunt, Jinquan Yu, Jonathan B. Spencer

Evidence that the Availability of an Allylic Hydrogen Governs the Regioselectivity of the Wacker Oxidation

Chem. Comm. 2001, 1844 (10.1039/B103066N)

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4. Matthew J. Gaunt, Jonathan B. Spencer

Derailing the Wacker Oxidation: Development of a Palladium-Catalyzed Amidation Reaction

Org. Lett. 2001, 3, 25 (10.1021/ol0066882)

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2. Matthew J. Gaunt, Carlos E. Boschetti, Jinquan Yu, Jonathan B. Spencer

Preferential Hydrogenolysis of NAP Esters Provides a New Orthogonal Protecting Group Strategy for Carboxylic Acids 

Tetrahedron Lett. 1999, 40, 1803 (10.1016/S0040-4039(99)00014-3)

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1. Matthew J. Gaunt, Jinquan Yu, Jonathan B. Spencer

Rational Design of Benzyl Type Protecting Groups Allows Sequential Deprotection of Hydroxyl Groups by Cata-lytic Hydrogenolysis 

J. Org. Chem. 1998, 63, 4172 (10.1021/jo980823v)