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PUBLICATIONS
102. Harry C. Waller, Matthew J. Gaunt
Silyl Radicals as Single-Electron Reductants: α-Aminoalkyl Radical Formation via a Photocatalytic Oxidatively Initiated Radical Chain Process
J. Am. Chem. Soc 2024, 146, 38, 25894 (10.1021/jacs.4c08230)
101. Jianzhong Liu, Matthew J. Gaunt
Versatile, Modular, and General Strategy for the Synthesis of α-Amino Carbonyls
J. Am. Chem. Soc 2024, 146, 35, 24699 (10.1021/jacs.4c09434)
100. Alex A. Rafaniello, Roopender Kumar, Rachel C. Phillips, Matthew J. Gaunt
Modular Synthesis of Heterobenzylic Amines via Carbonyl Azinylative Amination
Angew. Chem. Int. Ed. 2024, e202408287 (10.1002/anie.202408287)
99. Joseph M. Phelps, Roopender Kumar, James D. Robinson, John C. K. Chu, Nils J. Flodén, Sarah Beaton, Matthew J. Gaunt
Multicomponent Synthesis of α-Branched Amines via a Zinc-Mediated Carbonyl Alkylative Amination Reaction
J. Am. Chem. Soc 2024, 146, 13, 9045 (10.1021/jacs.3c14037)
98. Milo Smith, Ryan Kang, Roopender Kumar, Biswarup Roy, Matthew J. Gaunt
Modular Synthesis of alpha-Branched Secondary Alkylamines via Visible-light-mediated Carbonyl Alkylative Amination
Chem. Sci. 2024, 15, 14888 (10.1039/D4SC03916E)
97. Bo Li, Ala Bunescu, Daniel Drazen, Katherine Rolph, Jean Michalland, Matthew J. Gaunt
Modular synthesis of alkyl chlorides via visible light mediated dual catalyzed aryl-chlorination of alkenes
Angew. Chem. Int. Ed. 2024, 63, e202405939 (10.1002/anie.202405939)
96. Jacek Zakrzewski, Polina Yaseneva, Connor J. Taylor, Matthew J. Gaunt, Alexei A. Lapkin
Scalable Palladium-Catalyzed C(sp3)–H Carbonylation of Alkylamines in Batch and Continuous Flow
Org. Process Rev. Dev. 2023, 27, 649 (10.1021/acs.oprd.2c00378)
95. Georgia R. Harris, Aaron D. Trowbridge, Matthew J. Gaunt
A Chiral Amine Transfer Approach to the Photocatalytic Asymmetric Synthesis of α-Trialkyl-α-tertiary Amines
Org. Lett. 2023, 25, 861 (10.1021/acs.orglett.2c04308)
94. Bo Li, Ala Bunescu, Matthew J. Gaunt
Multicomponent synthesis of α-chloro alkylboronic esters via visible-light-mediated dual catalysis
Chem. 2022, 9, 216 (10.1016/j.chempr.2022.10.010)
93. Sanesh Mistry, Roopender Kumar, Andrew Lister, Matthew J. Gaunt
C(sp3)–C(sp3) coupling of non-activated alkyl-iodides with electron-deficient alkenes via visible-light/silane-mediated alkylradical formation
Chem. Sci. 2022, 13, 13241 (10.1039/D2SC03516B)
92. Alexander Pomberger, Antonio A. Pedrina McCarthy, Ahmad Khan, Simon Sung, Connor, J. Taylor,
Matthew J. Gaunt, Lucy Colwell, David Walz, Alexei A. Lapkin
The effect of chemical representation on active machine learning towards closed-loop optimization
React. Chem. Eng. 2022, 7, 1368 (10.1039/D2RE00008C)
91. Jesus Rodrigalvarez, Luke A. Reeve, Javier Miró, Matthew J. Gaunt
Pd(II)-Catalysed Enantioselective C(sp3)-H Arylation of Cyclopropanes and Cyclobutanes Guided by Tertiary Alkylamines
J. Am. Chem. Soc. 2022, 144, 3939 (10.1021/jacs.1c11921)
90. Keishi Kohara, Aaron Trowbridge, Milo A. Smith, Matthew J. Gaunt
Thiol-Mediated α-Amino Radical Formation via Visible-Light-Activated Ion-Pair Charge-Transfer Complexes
J. Am. Chem. Soc. 2021,143, 19268 (10.1021/jacs.1c09445)
89. J. Henry Blackwell, Georgia R. Harris, Milo A. Smith, Matthew J. Gaunt
Modular Photocatalytic Synthesis of α-Trialkyl-α-Tertiary Amines
J. Am. Chem. Soc. 2021,143, 15946 (10.1021/jacs.1c07402)
88. Matthew J. Gaunt, Jacob M. Janey, Danielle M. Schultz, Tim Cernak
Myths of high-throughput experimentation and automation in chemistry
Chem 2021, 7, 2259 (10.1016/j.chempr.2021.08.012)
87. Vivian M. Lechner, Manuel Nappi, Patrick J. Deneny, Sarah Folliet, John C. K. Chu, Matthew J. Gaunt
Visible-Light-Mediated Modification and Manipulation of Biomacromolecules
Chem. Rev. 2022, 122, 1752 (10.1021/acs.chemrev.1c00357)
86. Ala Bunescu, Yusra Abdelhamid, Matthew J. Gaunt
Multicomponent alkene azido-arylation by anion-mediated dual catalysis
Nature, 2021, 598, 597 (10.1038/s41586-021-03980-8)
85. Patrick J. Deneny, Roopender Kumar, Matthew J. Gaunt
Visible light-mediated radical fluoromethylation via halogen atom transfer activation of fluoroiodomethane
Chem. Sci. 2021,12, 12812 (10.1039/d1sc04554g)
84. J. Henry Blackwell, Roopender Kumar, Matthew J. Gaunt
Visible-Light-Mediated Carbonyl Alkylative Amination to All-Alkyl α-Tertiary Amino Acid Derivatives
J. Am. Chem. Soc. 2021,143, 3 (10.1021/jacs.0c12162)
83. Manuel Nappi, Alexandre Hofer, Shankar Balasubramanian, Matthew J. Gaunt
Selective Chemical Functionalization at N6-Methyladenosine Residues in DNA Enabled by Visible-Light-Mediated Photoredox Catalysis
J. Am. Chem. Soc. 2020, 142, 51 (10.1021/jacs.0c10616)
82. Kavoos Kolahdouzan, Roopender Kumar, Matthew J. Gaunt
Visible-light mediated carbonyl trifluoromethylative amination as a practical method for the synthesis of β-trifluoromethyl tertiary alkylamines.
Chem. Sci. 2020, 11 (10.1039/D0SC04853D)
81. William G. Whitehurst, Matthew J. Gaunt
Synthesis and Reactivity of Stable Alkyl-Pd(IV) Complexes Relevant to Monodentate N-directed C(sp3)–H Functionalization Processes
J. Am. Chem. Soc. 2020, 142, 33 (10.1021/jacs.0c04732)
80. Roopender Kumar, Nils J. Floden, William G. Whitehurst, Matthew J. Gaunt
A general carbonyl alkylative amination for tertiary amine synthesis
Nature, 2020, 581, 415 (10.1038/s41586-020-2213-0)
79. Aaron Trowbridge, Scarlett M. Walton, Matthew J. Gaunt
New Strategies for the Transition-Metal Catalyzed Synthesis of Aliphatic Amines
Chem. Rev. 2020, 120, 5 (10.1021/acs.chemrev.9b00462)
78. Jesus Rodrigalvarez, Manuel Nappi, Hiroki Azuma, Nils J. Floden, Matthew E. Burns, Matthew J. Gaunt
Catalytic C(sp3)–H bond activation in tertiary alkylamines
Nat. Chem. 2020, 12, 76 (10.1038/s41557-019-0393-8)
Highlighted in Synform, 2020/07, A99-A101 (10.1055/s-0039-1691185)
77. Dominik Reich, Aaron Trowbridge, Matthew J. Gaunt
Rapid syntheses of (−)‐FR901483 and (+)‐TAN1251C enabled by complexity‐generating photocatalytic olefin hydroaminoalkylation
Angew. Chem. Int. Ed. 2019, 59, 6 (10.1002/anie.201912010)
76. Nils J. Flodén, Aaron Trowbridge, Darren Willcox, Scarlett M. Walton, Yongjoon Kim, Matthew J. Gaunt
Streamlined synthesis of C(sp3)–H rich N-heterospirocycles enabled by visible-light-mediated photocatalysis
J. Am. Chem. Soc. 2019, 141, 8426 (110.1021/jacs.9b03372)
71. Michael T. Taylor, Jennifer E. Nelson, Marcos G. Suero, Matthew J. Gaunt
A Protein Functionalization Platform Based on Selective Reactions at Methionine Residues
Nature, 2018, 562, 568 (10.1038/s41586-018-0608-y)
70. Cornelia S. Buettner, Darren Willcox, Ben G. N. Chappell, Matthew J. Gaunt
Mechanistic Investigation into the C(sp3)–H Acetoxylation of Morpholinones
Chem. Sci., 2018, 10, 83 (10.1039/C8SC03434F)
72. Organometallics, 2018, 38, 143, A Class of N–O Type Oxidants to Access High-Valent Palladium Species
DOI:10.1021/acs.organomet.8b00712
75. William G. Whitehurst, J. Henry Blackwell, Gary N. Hermann, Matthew J. Gaunt
Carboxylate-Assisted Oxidative Addition to Aminoalkyl-Pd(II) Complexes Enables Catalyzed C(sp3)–H Arylation of Alkylamines via Distinct Pd(II)/Pd(IV) Pathway
Angew. Chem. Int. Ed., 2019, 58, 9054 (10.1002/anie.201902838)
74. Danny K. H. Ho, Jonas Calleja, Matthew J. Gaunt
Palladium(II)-Catalyzed C(sp3)–H Activation of N,O-Ketals towards a Method for the β-Functionalization of Ketones
Synlett, 2019, 30, 454 (10.1055/s-0037-1611664)
73. Chuan He, William G. Whitehurst, Matthew J. Gaunt
Palladium-Catalyzed C(sp3)–H Bond Functionalization of Aliphatic Amines
Chem, 2019, 5, 1 (10.1016/j.chempr.2018.12.017)
72. , Manuel Nappi, Matthew J. Gaunt
A Class of N–O-Type Oxidants To Access High-Valent Palladium Species
Organometallics, 2019, 38, 143 (10.1021/acs.organomet.8b00712)
69. Aaron Trowbridge, Dominik Reich, Matthew Gaunt
Multicomponent synthesis of tertiary alkylamines by photocatalytic olefin-hydroaminoalkylation
Nature, 2018, 561, 522 (10.1038/s41586-018-0537-9)
68. Zhuang Mao Png, Jaime R. Cabrera-Pardo, Jorge Peiró Cadahíaa, Matthew J. Gaunt
Diastereoselective C−H Carbonylative Annulation of Aliphatic Amines: A Rapid Route to Functionalized γ-Lactams
Chem. Sci., 2018, 9, 7628 (10.1039/C8SC02855A)
67. Manuel Nappi, Chuan He, William G. Whitehurst, Ben G. N. Chappell, Matthew J. Gaunt
Selective Reductive Elimination at Alkyl Pd(IV) via Dissociative Ligand Ionization Enables Catalytic C(sp3)−H Amination to Azetidines
Angew. Chem. Int. Ed., 2018, 57, 3178 (10.1002/anie.201800519)
66. Kirsten F. Hogg, Aaron Trowbridge, Andres Alvarez-Pérez, Matthew J. Gaunt
The α-Tertiary Amine Motif Drives Remarkable Selectivity for Palladium-Catalyzed Carbonylation of Methylene C−H Bonds
Chem. Sci., 2017, 8, 8198 (10.1039/C7SC03876C)
65. Jaime R. Cabrera‐Pardo, Aaron Trowbridge, Manuel Nappi, Kyohei Ozaki, Matthew J. Gaunt
Selective Palladium(II)-Catalyzed Carbonylation of β Methylene C−H Bonds in Aliphatic Amines
Angew. Chem. Int. Ed., 2017, 56, 11958 (10.1002/anie.201706303)
64. Daniel H. Lukamto, Matthew J. Gaunt
Enantioselective Copper-Catalyzed Arylation-Driven Semipinacol Rearrangement of Tertiary Allylic Alcohols with Diaryliodonium Salts
J. Am. Chem. Soc., 2017, 139, 9160 (10.1021/jacs.7b05340)
63. Chuan He, Matthew J. Gaunt
Ligand-Assisted Palladium-Catalyzed C−H Alkenylation of Aliphatic Amines for the Synthesis of Functionalized Pyrrolidines
Chem. Sci., 2017, 8, 3586 (10.1039/C7SC00468K)
62. Patrick Williamson, Alicia Galván, Matthew J. Gaunt
Cobalt-Catalyzed C−H Carbonylative Cyclisation of Aliphatic Amides
Chem. Sci., 2017, 8, 2588 (10.1039/C6SC05581H)
61. Adam P. Smalley, James D. Cuthbertson, Matthew J. Gaunt
Palladium-Catalyzed Enantioselective C−H Activation of Aliphatic Amines Using Chiral Anionic BINOL-Phosphoric Acid Ligands
J. Am. Chem. Soc., 2017, 139, 1412 (10.1021/jacs.6b12234)
60. Darren Willcox, Ben G. N. Chappell, Kirsten F. Hogg, Jonas Calleja, Adam P. Smalley, Matthew J. Gaunt
A General Catalytic β-C−H Carbonylation of Aliphatic Amines to β-Lactams
Science, 2016, 354, 851 (10.1126/science.aaf9621)
59. Rodolphe Beaud, Robert J. Phipps, Matthew J. Gaunt
Enantioselective Cu-Catalyzed Arylation of Secondary Phosphine Oxides with Diaryliodonium Salts towards the Synthesis of P-Chiral Phosphines
J. Am. Chem. Soc., 2016, 138, 13183 (10.1021/jacs.6b09334)
58. Jacek Zakrzewski, Adam P. Smalley, Mikhail A. Kabeshov, Matthew J. Gaunt, Alexei A. Lapkin
Continuous-Flow Synthesis and Derivitization of Aziridines through Palladium-Catalyzed C(sp3)−H Activation
Angew. Chem. Int. Ed., 2016, 55, 9024 (10.1002/anie.201602483)
57. , James C. Fox, Ruth E. Gilligan, Andrew K. Pitts, H. R. Bennett, Matthew J. Gaunt
The Total Synthesis of K-252c (Staurosporinone) via a Sequential C−H Functionalization Strategy
Chem. Sci., 2016, 7, 2706 (10.1039/C5SC04399A)
56. Alice E. Williamson, Tifelle Ngouansavanh, Robert D. M. Pace, Anna E. Allen, James D. Cuthbertson, Matthew J. Gaunt
Rapid Generation of Complex Molecular Architectures by a Catalytic Enantioselective Dearomatization Strategy
Synlett, 2016, 27, 116 (10.1055/s-0035-1560377)
55. Chuan He, Matthew J. Gaunt
Ligand-Enabled Catalytic C−H Arylation of Aliphatic Amines by a Four-Membered Ring Cyclopalladation Pathway
Angew. Chem. Int. Ed., 2015, 54, 15840 (10.1002/anie.201508912)
54. Jonas Calleja, Daniel Pla, Timothy W. Gorman, Victoriano Domingo, Benjamin Haffemayer, Matthew J. Gaunt
A Steric-Tethering Approach Enables Palladium-Catalyzed C−H Activation of Primary Amino Alcohols
Nat. Chem., 2015, 7, 1009 (10.1038/nchem.2367)
53. Adam P. Smalley, Matthew J. Gaunt
Mechanistic Insights Into the Palladium-Catalyzed Aziridination of Aliphatic Amines by C−H Activation
J. Am. Chem. Soc., 2015, 137, 10362 (10.1021/jacs.5b05529)
52. Elise Cahard, Henry P. J. Male, Matthieu Tissot, Matthew J. Gaunt
Enantioselective and Regiodivergent Copper-Catalyzed Electrophilic Arylation of Allylic Amides with Diaryliodonium Salts
J. Am. Chem. Soc., 2015, 137, 7986(10.1021/jacs.5b03937)
51. Dean Holt, Matthew J. Gaunt
Copper-Catalyzed Oxy-Alkenylation of Homoallylic Alcohols to Generate Functional Syn-1,3-Diol Derivatives
Angew. Chem. Int. Ed., 2015, 54, 7857 (10.1002/anie.201501995)
50. Andrew K. Pitts, Fionn O'Hara, Robert H. Snell, Matthew J. Gaunt
A Concise and Scalable Strategy for the Total Synthesis of Dictyodendrin B Based on Sequential C−H Functionalization
Angew. Chem. Int. Ed., 2015, 54, 5451 (10.1002/anie.201500067)
49. Louis Chan, Andrew McNally, Qiao Y. Toh, Abraham Mendoza, Mathew J. Gaunt
A Counterion Triggered Arylation Strategy Using Diaryliodonium Fluorides
Chem. Sci., 2015, 6, 1277 (10.1039/C4SC02856B)
48. Matthieu Tissot, Robert J. Phipps, Catherine Lucas, Rafael M. Leon, Robert D. M. Pace, Tifelle Ngouansavanh, Matthew J. Gaunt
Gram-Scale Enantioselective Formal Synthesis of Morphine Through an Ortho-Para Oxidative Phenolic Coupling Strategy
Angew. Chem. Int. Ed., 2014, 53, 13498 (10.1002/anie.201408435)
47. Fengzhi Zhang, Shoubhik Das, Andrew J. Walkinshaw, Alicia Casitas, Michael Taylor, Marcos G. Suero, Matthew J. Gaunt
Cu-Catalyzed Cascades to Carbocycles: Union of Diaryliodonium Salts with Alkenes or Alkynes Exploiting Remote Carbocations
J. Am. Chem. Soc., 2014, 136, 8851 (10.1021/ja504361y)
46. Andrew McNally, Benjamin Haffemayer, Beatrice S. L. Collins, Matthew J. Gaunt
Palladium-Catalyzed C−H Activation of Aliphatic Amines to Give Strained Nitrogen Heterocycles
Nature, 2014, 510, 129 (10.1038/nature13389)
45. Andrew J. Walkinshaw, Wenshu Xu, Marcos G. Suero, Matthew J. Gaunt
Copper-Catalyzed Carboarylation of Alkynes via Vinyl Cations
J. Am. Chem. Soc., 2013, 135, 12532 (10.1021/ja405972h)
44. Elise Cahard, Nadine Bremeyer, Matthew J. Gaunt
Copper-Catalyzed Intramolecular Electrophilic Carbofunctionalization of Allylic Amides
Angew. Chem. Int. Ed., 2013, 52, 9284 (10.1002/anie.201303724)
43. Beatrice S. L. Collins, Marcos G. Suero, Matthew J. Gaunt
Copper-Catalyzed Arylative Meyer-Schuster Rearrangement of Propargylic Alcohols to Complex Enones Using Diaryliodonium Salts
Angew. Chem. Int. Ed., 2013, 52, 5799 (10.1002/anie.201301529)
42., Marcos G. Suero, Elliott D. Bayle, Beatrice S. L. Collins, Matthew J. Gaunt
Copper-Catalyzed Electrophilic Carbofunctionalization of Alkynes to Highly Functionalized Tetrasubstituted Alkenes
J. Am. Chem. Soc., 2013, 135, 5322 (10.1021/ja401840j)
41. Qiao Yan Toh, Andrew McNally, Silvia Vera, Nico Erdmann, Matthew J. Gaunt
Organocatalytic C−H Bond Arylation of Aldehydes to Bis-Heteroaryl Ketones
J. Am. Chem. Soc., 2013, 135, 3772 (10.1021/ja400051d)
40. Lindsay McMurray, Elizabeth M. Beck, Matthew J. Gaunt
Chemical Synthesis of Aspidosperma Alkaloids Inspired by the Reverse of the Biosynthesis of the Rhazinilam Family of Natural Products
Angew. Chem. Int. Ed., 2012, 51, 9288 (10.1002/anie.201204151)
39. Robert J. Phipps, Lindsay McMurray, Stefanie Ritter, Hung A. Duong, Matthew J. Gaunt
Copper-Catalyzed Alkene Arylation with Diaryliodonium Salts
J. Am. Chem. Soc., 2012, 134, 10773 (10.1021/ja3039807)
38. Aurélien Bigot, Alice E. Williamson, Matthew J. Gaunt
Enantioselective α-Arylation of N-Acyloxazolidinones With Copper(II)-Bisoxazoline Catalysts and Diaryliodonium Salts
J. Am. Chem. Soc., 2011, 133, 13778 (10.1021/ja206047h)
37. Rafael Leon, Anup Jawalekar, Thomas Rederta, Matthew J. Gaunt
Catalytic Enantioselective Assembly of Complex Molecules Containing Embedded Quaternary Stereogenic Centres from Simple Anisidine Derivatives
Chem. Sci., 2011, 2, 1487 (10.1039/C1SC00218J)
36. Lindsay McMurray, Fionn O'Haraa, Matthew J. Gaunt
Recent Development in Natural Product Synthesis Using Metal-Catalyzed C−H Bond Functionalization
Chem. Soc. Rev., 2011, 40, 1885 (10.1039/C1CS15013H)
35. Matthew J. Tredwell, Moises Gulias, Nadine Bremeyer, Carin C. C. Johansson, Beatrice S. L. Collins, Matthew J. Gaunt
Palladium(II)-Catalyzed C−H Bond Arylation of Electron-Deficient Arenes at Room Temperature
Angew. Chem. Int. Ed., 2011, 50, 107610.1002/anie.201005990
34. Hung A. Duong, Ruth E. Gilligan, Michael L. Cooke, Robert J. Phipps, Matthew J. Gaunt
Copper(II)-Catalyzed Meta-Selective Direct Arylation of α-Aryl Carbonyl Compounds
Angew. Chem. Int. Ed., 2011, 50, 463 (10.1002/anie.201004704)
33. Claire‐Lise Ciana, Robert J. Phipps, Jochen R. Brandt, Falco‐Magnus Meyer, Matthew J. Gaunt
A Highly Para-Selective Copper(II)-Catalyzed Direct Arylation of Aniline and Phenol Derivatives
Angew. Chem. Int. Ed., 2011, 50, 458 (10.1002/anie.201004703)
32. Benjamin Haffemayer, Moises Guliasa, Matthew J. Gaunt
Amine Directed Pd(II)-Catalyzed C−H Bond Functionalization Under Ambient Conditions
Chem. Sci., 2011, 2, 312 (10.1039/C0SC00367K)
31. Neil P. Grimster, Donna A. A. Wilton, Louis K. M. Chan, Christopher R. A. Godfrey, Clive Green, Dafydd R. Owen, Matthew J.Gaunt
Alkynes to (E)-Enolates Using Tandem Catalysis: Stereoselective Anti-Aldol and Syn-[3,3]-Rearrangement Reactions
Tetrahedron, 2010, 66, 6429 (10.1016/j.tet.2010.05.045)
30. Robert J. Phipps, Matthew J. Gaunt
A Meta-Selective Copper-Catalyzed C−H Bond Arylation
Science, 2009, 323, 1593 (10.1126/science.1169975)
29. James A. Jordan-Hore, Carin C. C. Johansson, Moises Gulias, Elizabeth M. Beck, Matthew J. Gaunt
Oxidative Pd(II)-Catalyzed C−H Bond Amination to Carbazole at Ambient Temperature
J. Am. Chem. Soc., 2008, 130, 16184 (10.1021/ja806543s)
28. Robert J. Phipps, Neil P. Grimster, Matthew J. Gaunt
Cu(II)-Catalyzed Direct and Site-Selective Arylation of Indoles Under Mild Conditions
J. Am. Chem. Soc., 2008, 130, 8172 (10.1021/ja801767s)
27. Carin C. C. Johansson, Nadine Bremeyer, Steven V. Ley, Dafydd R. Owen, Stephen C. Smith, Matthew J. Gaunt
Synthesis of Rhazinicine by a Metal-Catalyzed C−H Bond Functionalization Strategy
Angew. Chem. Int. Ed., 2008, 47, 3004 (10.1002/ange.200602129)
26. Ngoc T. Vo, Robert D. M. Pace, Fionn O'Har, Matthew J. Gaunt
An Enantioselective Organocatalytic Oxidative Dearomatization Strategy
J. Am. Chem. Soc., 2008, 130, 40410.1021/ja077457u
25. Carin C. C. Johansson, Matthew J. Gaunt
Recent Developments in the Use of Catalytic Asymmetric Ammonium Enolates in Chemical Synthesis
Chem. Rev., 2007, 107, 5596 (10.1021/cr0683764)
24. Carin C. C. Johansson, Andy McNally, Ngoc T. Vo, Matthew J. Gaunt
Enantioselective Organocatalysis Review
Drug Discov. Today, 2007, 12, 8 (10.1016/j.drudis.2006.11.004)
23. Carin C. C. Johansson, Nadine Bremeyer, Steven V. Ley, Dafydd R. Owen, Stephen C. Smith, Matthew J. Gaunt
Enantioselective Catalytic Intramolecular Cyclopropanation Using Modified Cinchona Alkaloid Organocatalysts
Angew. Chem. Int. Ed., 2006, 45, 6024 (10.1002/anie.200602129)
22. Elizabeth M. Beck, Neil P. Grimster, Richard Hatley, Matthew J. Gaunt
Mild Aerobic Oxidative Palladium(II)-Catalyzed C−H Bond Functionalization: Regioselective and Switchable C−H Alkenylation and Annulation of Pyrroles
J. Am. Chem. Soc., 2006, 128, 2528 (10.1021/ja058141u)
21. Andrew McNally, Brian Evans, Matthew J. Gaunt
Organocatalytic Sigmatropic Reactions: Development of a [2,3]-Wittig Rearrangement Through Secondary Amine Catalysis
Angew. Chem. Int. Ed., 2006, 45, 2116 (10.1002/anie.200504301)
20. Neil P. Grimster, Carolyn Gauntlett, Christopher R. A. Godfrey, Matthew J. Gaunt
Palladium-Catalyzed Intermolecular Alkenylation of Indoles via Solvent-Controlled Regioselective C−H Functionalization
Angew. Chem. Int. Ed., 2005, 44, 3125 (10.1002/anie.200500468)
19. Charles D. Papageorgiou, Maria A. Cubillo de Dios, Steven V. Ley, Matthew J. Gaunt
Enantioselective Organocatalytic Cyclopropanation via Ammonium Ylides
Angew. Chem. Int. Ed., 2004, 43, 4641 (10.1002/anie.200460234)
18. Nadine Bremeyer, Stephen C. Smith, Steven V. Ley, Matthew J. Gaunt
An Intramolecular Organocatalytic Cyclopropanation Reaction
Angew. Chem. Int. Ed., 2004, 43, 2681 (10.1002/anie.200454007)
17. Charles D. Papageorgiou, Steven V. Ley, Matthew J. Gaunt
Organic-Catalyst-Mediated Cyclopropanation Reaction
Angew. Chem. Int. Ed., 2003, 42, 828 (10.1002/anie.200390222)
Postdoctoral Studies: Professor Steven Ley
16. Helen F. Sneddon,Alexandra van den Heuvel, Anna K. H. Hirsch, Richard A. Booth, David M. Shaw, Matthew J. Gaunt, Steven V. Ley
Double Conjugate Addition of Dithiols to Propargylic Carbonyl Systems to Generate Protected 1,3-Dicarbonyl Compounds
J. Org. Chem., 2006, 7, 2715 (10.1021/jo052514s)
15. Shigeru Kawahara, Matthew J. Gaunt, Alessandra Scolaro, Shigeo Yamanoi, Steven V. Ley
Synthesis of the EF Fragment of Spongistatin 1
Synlett, 2005, 13, 2031 (10.1055/s-2005-871960)
14. Matthew Ball, Matthew J. Gaunt, David F. Hook, Alan S. Jessiman, Shigeru Kawahara, Paolo Orsini, Alessandra Scolaro, Adam C. Talbot, Huw R. Tanner, Shigeo Yamanoi, Steven V. Ley
Total Synthesis of Spongistatin 1: Exploiting the Latent Pseudo-Symmetry
Angew. Chem. Int. Ed., 2005, 44, 5433 (10.1002/anie.200502008)
13. Matthew J. Gaunt, Alan S. Jessiman, Paolo Orsini, Huw R. Tanner, David F. Hook, Steven V. Ley
Synthesis of C-1-C-28 ABCD Unit of Spongistatin 1
Org. Lett., 2003, 5, 4819 (10.1021/ol035849+)
12. Matthew J. Gaunt, David F. Hook, Huw R. Tanner, Steven V. Ley
A Practical and Efficient Synthesis of the C-16-C-28 Spiroketal Fragment (CD) of the Spongistatins
Org. Lett., 2003, 5, 4815 (10.1021/ol035848h)
11. Helen F. Sneddon, Matthew J. Gaunt, Steven V. Ley
Addition of Dithiols to Bis-Ynones: Development of a Versatile Platform for the Synthesis of Polyketide Natural Products
Org. Lett., 2003, 5, 1147 (10.1021/ol034248f)
10. Matthew J. Gaunt, Helen F. Sneddon, Peter R. Hewitt, Paolo Orsini, David F. Hooka, Steven V. Ley
Development of β-Keto 1,3-Dithianes as Versatile Intermediates for Organic Synthesis
Org. Biomol. Chem., 2003, 1, 15 (10.1039/B208982C)
Postdoctoral Studies (with Professor Amos Smith)
9. Amos B. Smith, Suresh M. Pitram, Armen M. Boldi, Matthew J. Gaunt, Chris Sfouggatakis, William H. Moser
Multicomponent Linchpin Couplings. Reaction of Dithiane Anions with Epoxides, Epichlorohydrin and Vinyl Epoxides: Efficient, Rapid and Stereocontrolled Assembly of Advanced Fragments for Complex Molecule Synthesis
J. Am. Chem. Soc. 2003, 125, 14435 (10.1021/ja0376238)
8. Amos B. Smith, Suresh M. Pitram, Matthew J. Gaunt, Sergey A. Kozmin
Dithiane Additions to Vinyl Epoxides: Steric Control Over SN2 and SN2' Manifolds
J. Am. Chem. Soc. 2002, 124, 14516 (10.1021/ja0283100)
PhD Studies (with Dr Jonathan Spencer)
7. Joseph A. Wright, Matthew J. Gaunt, Jonathan B. Spencer
Novel Anti-Markovnikov Regioselectivity in the Wacker Reaction of Styrenes
Chem. Eur. J. 2006, 12, 949 (10.1002/chem.200400644)
6. Jinquan Yu, Matthew J. Gaunt, Jonathan B. Spencer
Convenient Preparation of Pure Trans-Arylalkenes via Palladium(II)-Catalyzed Isomerization of the Cis-Alkenes
J. Org. Chem. 2002, 67, 4627 (10.1021/jo015880u)
5. Matthew J. Gaunt, Jinquan Yu, Jonathan B. Spencer
Evidence that the Availability of an Allylic Hydrogen Governs the Regioselectivity of the Wacker Oxidation
Chem. Comm. 2001, 1844 (10.1039/B103066N)
4. Matthew J. Gaunt, Jonathan B. Spencer
Derailing the Wacker Oxidation: Development of a Palladium-Catalyzed Amidation Reaction
Org. Lett. 2001, 3, 25 (10.1021/ol0066882)
3. Edward A. Papageorgiou, Matthew J. Gaunt, Jinquan Yu, Jonathan B. Spencer
Selective Hydrogenolysis of Novel Benzyl Carbamate Protecting Groups
Org. Lett. 2000, 2, 1049 (10.1021/ol005589l)
2. Matthew J. Gaunt, Carlos E. Boschetti, Jinquan Yu, Jonathan B. Spencer
Preferential Hydrogenolysis of NAP Esters Provides a New Orthogonal Protecting Group Strategy for Carboxylic Acids
Tetrahedron Lett. 1999, 40, 1803 (10.1016/S0040-4039(99)00014-3)
1. Matthew J. Gaunt, Jinquan Yu, Jonathan B. Spencer
Rational Design of Benzyl Type Protecting Groups Allows Sequential Deprotection of Hydroxyl Groups by Cata-lytic Hydrogenolysis
J. Org. Chem. 1998, 63, 4172 (10.1021/jo980823v)
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