PUBLICATIONS
91. Alexander Pomberger, Antonio A. Pedrina McCarthy, Ahmad Khan, Simon Sung, Connor, J. Taylor,
Matthew J. Gaunt, Lucy Colwell, David Walz, Alexei A. Lapkin
The effect of chemical representation on active machine learning towards closed-loop optimization
React. Chem. Eng. 2022 (10.1039/D2RE00008C)
90. Jesus Rodrigalvarez, Luke A. Reeve, Javier Miró, Matthew J. Gaunt
Pd(II)-Catalysed Enantioselective C(sp3)-H Arylation of Cyclopropanes and Cyclobutanes Guided by Tertiary Alkylamines
J. Am. Chem. Soc. 2022, 144, 3939 (10.1021/jacs.1c11921)
89. Keishi Kohara, Aaron Trowbridge, Milo A. Smith, Matthew J. Gaunt
Thiol-Mediated α-Amino Radical Formation via Visible-Light-Activated Ion-Pair Charge-Transfer Complexes
J. Am. Chem. Soc. 2021,143, 19268 (10.1021/jacs.1c09445)
88. J. Henry Blackwell, Georgia R. Harris, Milo A. Smith, Matthew J. Gaunt
Modular Photocatalytic Synthesis of α-Trialkyl-α-Tertiary Amines
J. Am. Chem. Soc. 2021,143, 15946 (10.1021/jacs.1c07402)
87. Vivian M. Lechner, Manuel Nappi, Patrick J. Deneny, Sarah Folliet, John C. K. Chu, Matthew J. Gaunt
Visible-Light-Mediated Modification and Manipulation of Biomacromolecules
Chem. Rev. 2022, 122, 1752 (10.1021/acs.chemrev.1c00357)
86. Ala Bunescu, Yusra Abdelhamid, Matthew J. Gaunt
Multicomponent alkene azido-arylation by anion-mediated dual catalysis
Nature, 2021, 598, 597 (10.1038/s41586-021-03980-8)
85. Patrick J. Deneny, Roopender Kumar, Matthew J. Gaunt
Visible light-mediated radical fluoromethylation via halogen atom transfer activation of fluoroiodomethane
Chem. Sci. 2021,12, 12812 (10.1039/d1sc04554g)
84. J. Henry Blackwell, Roopender Kumar, Matthew J. Gaunt
Visible-Light-Mediated Carbonyl Alkylative Amination to All-Alkyl α-Tertiary Amino Acid Derivatives
J. Am. Chem. Soc. 2021,143, 3 (10.1021/jacs.0c12162)
83. Manuel Nappi, Alexandre Hofer, Shankar Balasubramanian, Matthew J. Gaunt
Selective Chemical Functionalization at N6-Methyladenosine Residues in DNA Enabled by Visible-Light-Mediated Photoredox Catalysis
J. Am. Chem. Soc. 2020, 142, 51 (10.1021/jacs.0c10616)
82. Kavoos Kolahdouzan, Roopender Kumar, Matthew J. Gaunt
Visible-light mediated carbonyl trifluoromethylative amination as a practical method for the synthesis of β-trifluoromethyl tertiary alkylamines.
Chem. Sci. 2020, 11 (10.1039/D0SC04853D)
81. William G. Whitehurst, Matthew J. Gaunt
Synthesis and Reactivity of Stable Alkyl-Pd(IV) Complexes Relevant to Monodentate N-directed C(sp3)–H Functionalization Processes
J. Am. Chem. Soc. 2020, 142, 33 (10.1021/jacs.0c04732)
80. Roopender Kumar, Nils J. Floden, William G. Whitehurst, Matthew J. Gaunt
A general carbonyl alkylative amination for tertiary amine synthesis
Nature, 2020, 581, 415 (10.1038/s41586-020-2213-0)
79. Aaron Trowbridge, Scarlett M. Walton, Matthew J. Gaunt
New Strategies for the Transition-Metal Catalyzed Synthesis of Aliphatic Amines
Chem. Rev. 2020, 120, 5 (10.1021/acs.chemrev.9b00462)
78. Jesus Rodrigalvarez, Manuel Nappi, Hiroki Azuma, Nils J. Floden, Matthew E. Burns, Matthew J. Gaunt
Catalytic C(sp3)–H bond activation in tertiary alkylamines
Nat. Chem. 2020, 12, 76 (10.1038/s41557-019-0393-8)
Highlighted in Synform, 2020/07, A99-A101 (10.1055/s-0039-1691185)
77. Dominik Reich, Aaron Trowbridge, Matthew J. Gaunt
Rapid syntheses of (−)‐FR901483 and (+)‐TAN1251C enabled by complexity‐generating photocatalytic olefin hydroaminoalkylation
Angew. Chem. Int. Ed. 2019, 59, 6 (10.1002/anie.201912010)
76. Nils J. Flodén, Aaron Trowbridge, Darren Willcox, Scarlett M. Walton, Yongjoon Kim, Matthew J. Gaunt
Streamlined synthesis of C(sp3)–H rich N-heterospirocycles enabled by visible-light-mediated photocatalysis
J. Am. Chem. Soc. 2019, 141, 8426 (110.1021/jacs.9b03372)
71. Michael T. Taylor, Jennifer E. Nelson, Marcos G. Suero, Matthew J. Gaunt
A Protein Functionalization Platform Based on Selective Reactions at Methionine Residues
Nature, 2018, 562, 568 (10.1038/s41586-018-0608-y)
70. Cornelia S. Buettner, Darren Willcox, Ben G. N. Chappell, Matthew J. Gaunt
Mechanistic Investigation into the C(sp3)–H Acetoxylation of Morpholinones
Chem. Sci., 2018, 10, 83 (10.1039/C8SC03434F)
72. Organometallics, 2018, 38, 143, A Class of N–O Type Oxidants to Access High-Valent Palladium Species
DOI:10.1021/acs.organomet.8b00712
75. William G. Whitehurst, J. Henry Blackwell, Gary N. Hermann, Matthew J. Gaunt
Carboxylate-Assisted Oxidative Addition to Aminoalkyl-Pd(II) Complexes Enables Catalyzed C(sp3)–H Arylation of Alkylamines via Distinct Pd(II)/Pd(IV) Pathway
Angew. Chem. Int. Ed., 2019, 58, 9054 (10.1002/anie.201902838)
74. Danny K. H. Ho, Jonas Calleja, Matthew J. Gaunt
Palladium(II)-Catalyzed C(sp3)–H Activation of N,O-Ketals towards a Method for the β-Functionalization of Ketones
Synlett, 2019, 30, 454 (10.1055/s-0037-1611664)
73. Chuan He, William G. Whitehurst, Matthew J. Gaunt
Palladium-Catalyzed C(sp3)–H Bond Functionalization of Aliphatic Amines
Chem, 2019, 5, 1 (10.1016/j.chempr.2018.12.017)
72. , Manuel Nappi, Matthew J. Gaunt
A Class of N–O-Type Oxidants To Access High-Valent Palladium Species
Organometallics, 2019, 38, 143 (10.1021/acs.organomet.8b00712)
69. Aaron Trowbridge, Dominik Reich, Matthew Gaunt
Multicomponent synthesis of tertiary alkylamines by photocatalytic olefin-hydroaminoalkylation
Nature, 2018, 561, 522 (10.1038/s41586-018-0537-9)
68. Zhuang Mao Png, Jaime R. Cabrera-Pardo, Jorge Peiró Cadahíaa, Matthew J. Gaunt
Diastereoselective C−H Carbonylative Annulation of Aliphatic Amines: A Rapid Route to Functionalized γ-Lactams
Chem. Sci., 2018, 9, 7628 (10.1039/C8SC02855A)
67. Manuel Nappi, Chuan He, William G. Whitehurst, Ben G. N. Chappell, Matthew J. Gaunt
Selective Reductive Elimination at Alkyl Pd(IV) via Dissociative Ligand Ionization Enables Catalytic C(sp3)−H Amination to Azetidines
Angew. Chem. Int. Ed., 2018, 57, 3178 (10.1002/anie.201800519)
66. Kirsten F. Hogg, Aaron Trowbridge, Andres Alvarez-Pérez, Matthew J. Gaunt
The α-Tertiary Amine Motif Drives Remarkable Selectivity for Palladium-Catalyzed Carbonylation of Methylene C−H Bonds
Chem. Sci., 2017, 8, 8198 (10.1039/C7SC03876C)
65. Jaime R. Cabrera‐Pardo, Aaron Trowbridge, Manuel Nappi, Kyohei Ozaki, Matthew J. Gaunt
Selective Palladium(II)-Catalyzed Carbonylation of β Methylene C−H Bonds in Aliphatic Amines
Angew. Chem. Int. Ed., 2017, 56, 11958 (10.1002/anie.201706303)
64. Daniel H. Lukamto, Matthew J. Gaunt
Enantioselective Copper-Catalyzed Arylation-Driven Semipinacol Rearrangement of Tertiary Allylic Alcohols with Diaryliodonium Salts
J. Am. Chem. Soc., 2017, 139, 9160 (10.1021/jacs.7b05340)
63. Chuan He, Matthew J. Gaunt
Ligand-Assisted Palladium-Catalyzed C−H Alkenylation of Aliphatic Amines for the Synthesis of Functionalized Pyrrolidines
Chem. Sci., 2017, 8, 3586 (10.1039/C7SC00468K)
62. Patrick Williamson, Alicia Galván, Matthew J. Gaunt
Cobalt-Catalyzed C−H Carbonylative Cyclisation of Aliphatic Amides
Chem. Sci., 2017, 8, 2588 (10.1039/C6SC05581H)
61. Adam P. Smalley, James D. Cuthbertson, Matthew J. Gaunt
Palladium-Catalyzed Enantioselective C−H Activation of Aliphatic Amines Using Chiral Anionic BINOL-Phosphoric Acid Ligands
J. Am. Chem. Soc., 2017, 139, 1412 (10.1021/jacs.6b12234)
60. Darren Willcox, Ben G. N. Chappell, Kirsten F. Hogg, Jonas Calleja, Adam P. Smalley, Matthew J. Gaunt
A General Catalytic β-C−H Carbonylation of Aliphatic Amines to β-Lactams
Science, 2016, 354, 851 (10.1126/science.aaf9621)
59. Rodolphe Beaud, Robert J. Phipps, Matthew J. Gaunt
Enantioselective Cu-Catalyzed Arylation of Secondary Phosphine Oxides with Diaryliodonium Salts towards the Synthesis of P-Chiral Phosphines
J. Am. Chem. Soc., 2016, 138, 13183 (10.1021/jacs.6b09334)
58. Jacek Zakrzewski, Adam P. Smalley, Mikhail A. Kabeshov, Matthew J. Gaunt, Alexei A. Lapkin
Continuous-Flow Synthesis and Derivitization of Aziridines through Palladium-Catalyzed C(sp3)−H Activation
Angew. Chem. Int. Ed., 2016, 55, 9024 (10.1002/anie.201602483)
57. , James C. Fox, Ruth E. Gilligan, Andrew K. Pitts, H. R. Bennett, Matthew J. Gaunt
The Total Synthesis of K-252c (Staurosporinone) via a Sequential C−H Functionalization Strategy
Chem. Sci., 2016, 7, 2706 (10.1039/C5SC04399A)
56. Alice E. Williamson, Tifelle Ngouansavanh, Robert D. M. Pace, Anna E. Allen, James D. Cuthbertson, Matthew J. Gaunt
Rapid Generation of Complex Molecular Architectures by a Catalytic Enantioselective Dearomatization Strategy
Synlett, 2016, 27, 116 (10.1055/s-0035-1560377)
55. Chuan He, Matthew J. Gaunt
Ligand-Enabled Catalytic C−H Arylation of Aliphatic Amines by a Four-Membered Ring Cyclopalladation Pathway
Angew. Chem. Int. Ed., 2015, 54, 15840 (10.1002/anie.201508912)
54. Jonas Calleja, Daniel Pla, Timothy W. Gorman, Victoriano Domingo, Benjamin Haffemayer, Matthew J. Gaunt
A Steric-Tethering Approach Enables Palladium-Catalyzed C−H Activation of Primary Amino Alcohols
Nat. Chem., 2015, 7, 1009 (10.1038/nchem.2367)
53. Adam P. Smalley, Matthew J. Gaunt
Mechanistic Insights Into the Palladium-Catalyzed Aziridination of Aliphatic Amines by C−H Activation
J. Am. Chem. Soc., 2015, 137, 10362 (10.1021/jacs.5b05529)



52. Elise Cahard, Henry P. J. Male, Matthieu Tissot, Matthew J. Gaunt
Enantioselective and Regiodivergent Copper-Catalyzed Electrophilic Arylation of Allylic Amides with Diaryliodonium Salts
J. Am. Chem. Soc., 2015, 137, 7986(10.1021/jacs.5b03937)
51. Dean Holt, Matthew J. Gaunt
Copper-Catalyzed Oxy-Alkenylation of Homoallylic Alcohols to Generate Functional Syn-1,3-Diol Derivatives
Angew. Chem. Int. Ed., 2015, 54, 7857 (10.1002/anie.201501995)



50. Andrew K. Pitts, Fionn O'Hara, Robert H. Snell, Matthew J. Gaunt
A Concise and Scalable Strategy for the Total Synthesis of Dictyodendrin B Based on Sequential C−H Functionalization
Angew. Chem. Int. Ed., 2015, 54, 5451 (10.1002/anie.201500067)



49. Louis Chan, Andrew McNally, Qiao Y. Toh, Abraham Mendoza, Mathew J. Gaunt
A Counterion Triggered Arylation Strategy Using Diaryliodonium Fluorides
Chem. Sci., 2015, 6, 1277 (10.1039/C4SC02856B)
48. Matthieu Tissot, Robert J. Phipps, Catherine Lucas, Rafael M. Leon, Robert D. M. Pace, Tifelle Ngouansavanh, Matthew J. Gaunt
Gram-Scale Enantioselective Formal Synthesis of Morphine Through an Ortho-Para Oxidative Phenolic Coupling Strategy
Angew. Chem. Int. Ed., 2014, 53, 13498 (10.1002/anie.201408435)



47. Fengzhi Zhang, Shoubhik Das, Andrew J. Walkinshaw, Alicia Casitas, Michael Taylor, Marcos G. Suero, Matthew J. Gaunt
Cu-Catalyzed Cascades to Carbocycles: Union of Diaryliodonium Salts with Alkenes or Alkynes Exploiting Remote Carbocations
J. Am. Chem. Soc., 2014, 136, 8851 (10.1021/ja504361y)
46. Andrew McNally, Benjamin Haffemayer, Beatrice S. L. Collins, Matthew J. Gaunt
Palladium-Catalyzed C−H Activation of Aliphatic Amines to Give Strained Nitrogen Heterocycles
Nature, 2014, 510, 129 (10.1038/nature13389)


